Recombinant Human GDF-6 Protein
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Growth and Differentiation Factors (GDF) are members of the BMP family of TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues.
SKU | OPTIONS | 价格 | |
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GDF6-100 | 50 ug (1 mg/ml) | Please inquire | |
GDF6-200 | 1 mg (1 mg/ml) | Please inquire | |
GDF6-300 | 100 mg (10 mg/ml) | Please inquire | |
GDF6-400 | 1 g (10 mg/ml) | Please inquire | |
GDF6-OEM | Any size | Please inquire |
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描述
Description
Growth and Differentiation Factors (GDF) are members of the BMP family of TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis.
GDF-6, also known as BMP-13 or cartilage-derived morphogenetic protein 2 (CDMP-2), has multiple functions including regulation of myogenesis, regulation of chondrogenesis, bone morphogenesis, and neuron differentiation and survival. GDF-6 response is mediated by the formation of hetero-oligomeric complexes of type I (BMPR-IB) and type II (BMPR-II or Activin R-II) sereine/threonine kinase receptors, and the activation of Smad proteins (Smad 1, 5, and 8).
Full Name
Growth and Differentiation Factor 6
Source
E. coli
Species
Human
Accession #
Q6KF10
Molecule Weight
The mature recombinant human GDF-6 is a 14 kDa protein (336-455aa).
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is in the range of 2-3 ug/mL.
Storage
-80 Avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
其他信息
OPTIONS | 50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size |
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