Recombinant Human GDF-9 Protein

描述

Description
Growth and Differentiation Factors (GDF) are members of the BMP family of TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis.
GDF-9 is expressed in oocytes and is required for normal ovarian folliculogenesis. GDF-9 functions as a paracrine factor in the development of primary follicles in the ovary. It is critical for the growth of granulosa and theca cells and for the differentiation and maturation of the oocyte. GDF-9 is thought to act synergistically with BMP-15 to control development of the oocyte-cumulus cell complex.

Full Name
Growth and Differentiation Factor 9

Source
E. coli

Species
Human

Accession #
O60383

Molecule Weight
The mature recombinant human GDF-9 is a 16 kDa protein (320-454aa).

Purity
> 95 % as determined by SDS-PAGE

Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method

Activity
Measured by its ability to induce cell death using Mv1Lu mink lung epithelial cells. The ED50 for this effect is 50-250 ng/mL.

Storage
-80     Avoid repeated freeze-thaw cycles.

Storage Buffer
PBS

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