内切酶V,大肠杆菌

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Endonuclease V, (Endo V) is a 3′-endonuclease involved in DNA repair, which initiates removal of deaminated bases from damaged DNA, including uracil, hypoxanthine, and xanthine.

SKU: SKU49545 Categories: ,
SKU OPTIONS 价格
ENV-100 50 ug (1 mg/ml) Please inquire
ENV-200 1 mg (1 mg/ml) Please inquire
ENV-300 100 mg (10 mg/ml) Please inquire
ENV-400 1 g (10 mg/ml) Please inquire
ENV-OEM Any size Please inquire

Description

Description
Endonuclease V, (Endo V) is a 3′-endonuclease involved in DNA repair, which initiates removal of deaminated bases from damaged DNA, including uracil, hypoxanthine, and xanthine.

Endonuclease V is also active toward abasic sites and urea sites, base pair mismatches, flap and pseudo Y structures, and small insertions/deletions in DNA molecules. The cleavage site generated by Endonuclease V is at the second phosphodiester bond 3′ to a lesion.

Applications
• High-throughput methods for mutation research
• Studies in mutagenesis and DNA repair
• Mismatch cleavage
• Genotyping

Source
E. coli

Purity
> 95 % as determined by SDS-PAGE

Storage
-80 Avoid repeated freeze-thaw cycles.

Unit Definition
One unit of T4 Endonuclease V converts 1 µg of UV-irradiated plasmid DNA from covalently closed circles to nicked form in 30 minutes at 37°C.

Additional information

OPTIONS

50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size

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