Recombinant Human Ang-1 Protein
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Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system.
| SKU | OPTIONS | 价格 | |
|---|---|---|---|
| ANG1-100 | 50 ug (1 mg/ml) | Please inquire | |
| ANG1-200 | 1 mg (1 mg/ml) | Please inquire | |
| ANG1-300 | 100 mg (10 mg/ml) | Please inquire | |
| ANG1-400 | 1 g (10 mg/ml) | Please inquire | |
| ANG1-OEM | Any size | Please inquire |
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描述
Description
Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. It signals through the receptor tyrosine kinase Tie-2 and binds a variety of integrins and the extracellular matrix. Angiopoietin-1 induces the development and branching of blood vessels, promotes vascular endothelial cell motility during angiogenesis, and enhances vascular integrity. It can suppress several VEGF-induced effects on the vasculature. Angiopoietin-1 can protect against pulmonary arterial hypertension, reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium, and enhance tumor progression and metastasis.
Full Name
Angiopoietin-1
Source
E. coli
Species
Human
Accession #
Q5HYA0
Molecule Weight
The mature recombinant human Ang-1 is a 56 kDa protein containing 479aa (S20-F498).
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured by its ability to inhibit serum deprivation induced apoptosis in HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 10-40 ng/mL.
Storage
-80 Avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
其他信息
| OPTIONS | 50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size |
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