Recombinant Human TGF-beta 3 Protein
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TGF-beta 3 (transforming growth factor beta 1) is one of three closely related mammalian members, TGF-beta 1, -2 and -3 , of the large TGF-beta superfamily that share a characteristic cystine knot structure. These three TGF-beta isoforms are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition.
| SKU | OPTIONS | 价格 | |
|---|---|---|---|
| TGFb 3-100 | 50 ug (1 mg/ml) | Please inquire | |
| TGFb 3-200 | 1 mg (1 mg/ml) | Please inquire | |
| TGFb 3-300 | 100 mg (10 mg/ml) | Please inquire | |
| TGFb 3-400 | 1 g (10 mg/ml) | Please inquire | |
| TGFb 3-OEM | Any size | Please inquire |
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描述
Description
TGF-beta 3 (transforming growth factor beta 1) is one of three closely related mammalian members, TGF-beta 1, -2 and -3 , of the large TGF-beta superfamily that share a characteristic cystine knot structure. These three TGF-beta isoforms are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix.
TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF- beta RI or ALK-1, to modulate transcription through Smad phosphorylation.
Full Name
Transforming growth factor beta 3
Source
E. coli
Species
Human
Accession #
P10600
Molecule Weight
The mature recombinant human TGF-beta 3 consists of 112 amino acids (301-412) and has a predicted molecular mass of 12.7 kDa.
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 0.1 EU per μg of the protein as determined by the LAL method
Activity
Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. The ED50 for this effect is 0.01-0.04 ng/mL.
Storage
-80 Avoid repeated freeze-thaw cycles.
Storage Buffer
PBS
其他信息
| OPTIONS | 50 ug (1 mg/ml), 1 mg (1 mg/ml), 100 mg (10 mg/ml), 1 g (10 mg/ml), Any size |
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